Acetic Anhydride → HCID 13066716, compound

HRID 1164087Notes

Reaction equation

HRID 1164087 reaction equation
CO[C:3]1[C:8]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])=[CH:7][CH:6]=[CH:5][C:4]=1[CH:17]([CH3:21])[C:18]([OH:20])=[O:19].C(OC(=O)C)(=O)C>I>[CH3:21][CH:17]1[C:4]2[CH:5]=[CH:6][CH:7]=[C:8]([S:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[Cl:16])[C:3]=2[O:19][C:18]1=[O:20]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 20513441HCID 20513441, compound

Product 1

HCID 13066716HCID 13066716, compoundYield 81.8%

Reagents, catalysts & solvents 1

HCID 24841Hydrogen iodideSolvent

Procedure

2-[2-Methoxy-3-(2-chlorophenylthio)phenyl]propionic acid (1.9 g), acetic anhydride (5 ml) and hydriodic acid (58%, 10 ml) were treated in a similar manner to that of Example 21-(9) to give oily 3-methyl-7-(2-chlorophenylthio)-2,3-dihydrobenzofuran-2-one (1.4 g). This product was subjected to column chromatography (silica gel 30 g, benzene), and the resultant oily substance was crystallized with ethanol to give crystaline product (1.2 g), mp. 63°-64° C.

Sources & evidence

ORD record
ord-6150022d9bef43ea8c284385e1a6d7c1
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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