反应详情

to a solution of 2.43 g of arabinofuranosylcytosine dissolved in 40 ml of dimethylacetamide, there is added 10 ml of a toluene solution containing 3.0 g of potassium hydrogen carbonate and 5.8 g of behenyloxycarbonyl chloride. The reaction is carried out at room temperature with stirring of the mixture for 4 hours. After completion of the reaction, the mixture is poured into ice-water and the precipitated solids are collected by filtration, followed by washing successively with acetone and with chloroform. The white solids obtained are dissolved in a mixture of chloroform-methanol and the resultant insolubles are filtered off. After removal of the solvent, the rersidue is subjected to precipitation from chloroform to obtain 2.0 g of N4 -behenyloxy-1-β-D-arabino-furanosylcytosine (Yield:35%).

1. customis carried out at room temperature
2. customAfter completion of the reaction
3. filtrationthe precipitated solids are collected by filtration
4. washby washing successively with acetone and with chloroform
5. customThe white solids obtained
6. filtrationthe resultant insolubles are filtered off
7. customAfter removal of the solvent
8. customthe rersidue is subjected to precipitation from chloroform