Hydrochloric Acid → HCID 178433555, compound

HRID 1164222Notes

Reaction equation

HRID 1164222 reaction equation
[NH2:1][C:2](=[S:17])[NH:3][N:4]([C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1)[C:5](=O)[CH3:6].Cl>[OH-].[Na+].O>[CH3:6][C:5]1[N:4]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=2)[N:3]=[C:2]([SH:17])[N:1]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 15581904HCID 15581904, compound

Product 1

HCID 178433555HCID 178433555, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

40 Parts of acetic acid, 2-(aminothioxomethyl)-1-(4-nitrophenyl)hydrazide are dissolved in a mixture of 10 parts of sodium hydroxide and 400 parts of water and the solution is stirred for 30 minutes at room temperature. The reaction mixture is acidified with concentrated hydrochloric acid. The precipitated product is filtered off, washed with water and with 2-propanol and crystallized from 1,4-dioxane, yielding 22.4 parts of 5-methyl-1-(4-nitrophenyl)-1H-1,2,4-triazole-3-thiol; mp. 202.1° C.

Workup

  1. filtrationThe precipitated product is filtered off
  2. washwashed with water and with 2-propanol
  3. customcrystallized from 1,4-dioxane

Sources & evidence

ORD record
ord-c2792aaba5c94b9b9f3c0dc185d81053
Source dataset
uspto-grants-1983_01
Patent number
US04368200

Reaction notes

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