HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3-Methoxy-1,2,4,5-tetramethylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 2,3,5,6-Tetramethylphenol | HCID 10694 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-Methoxy-1,2,4,5-tetramethylbenzene | HCID 278664 | — |
Reaction Steps
In 150 ml of DMSO were dissolved 15.0 g of 2,3,5,6-tetramethylphenol and 28 ml of methyl iodide. Under ice-cooling 6.3 g of 60% sodium hydride in oil was added, and the mixture was stirred at room temperature for 1 hour. The excess sodium hydride was decomposed with MeOH and after addition of water extraction with ether was carried out. The extract was dried over sodium sulfate. Removal of the solvent by distillation leaves crystals which were recrystallized from MeOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04368150 |
| Source dataset | uspto-grants-1983_01 |
| ORD ID | ord-655501f6e8924ea0b35aba1e4c8912f1 |
| Source note | uspto-grants-1983_01 |