反应详情

40.0 g. of p-methoxybenzoyl chloride, 25.0 g. of 2-pyrrolidinone and 110 ml. of absolute diethyl ether are treated at between 0° C. and 10° C. while stirring with 52.5 ml. of triethylamine. The mixture is stirred at room temperature for a further 30 minutes and at reflux for 3 hours, then cooled down and treated at 2° C. with cold water. The insoluble constituents are filtered off under suction and washed with water and diethyl ether. The thus-obtained solid substance is recrystallized from alcohol after drying over phosphorus pentoxide. There is obtained 1-(p-methoxybenzoyl)-2-pyrrolidinone which melts at 121°-122° C.

1. stirringThe mixture is stirred at room temperature for a further 30 minutes
2. temperatureat reflux for 3 hours
3. temperaturecooled down
4. filtrationThe insoluble constituents are filtered off under suction
5. washwashed with water and diethyl ether
6. customThe thus-obtained solid substance is recrystallized from alcohol
7. dry with materialafter drying over phosphorus pentoxide