p-Anisoyl chloride → Aniracetam

HRID 1164300Notes

Reaction equation

HRID 1164300 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].[CH3:7][O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13](Cl)=[O:14])=[CH:11][CH:10]=1>>[CH3:7][O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([N:1]2[CH2:5][CH2:4][CH2:3][C:2]2=[O:6])=[O:14])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 120252-Pyrrolidone

Product 1

HCID 2196Aniracetam

Procedure

10 g. of 2-pyrrolidinone and 10 g. of p-methoxybenzoyl chloride are heated at 80°-90° C. (internal temperature) in the absence of a solvent for 1 hour. The mixture is then left to cool down and is worked-up as described in Example 3. After recrystallization from alcohol, there is obtained 1-(p-methoxybenzoyl)-2-pyrrolidinone having a melting point of 120°-121° C.

Workup

  1. waitThe mixture is then left
  2. temperatureto cool down
  3. customAfter recrystallization from alcohol

Sources & evidence

ORD record
ord-517ed659ea52430a810bd989ac5a1031
Source dataset
uspto-grants-1983_01
Patent number
US04369139

Reaction notes

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