p-Anisoyl chloride → Aniracetam

Participants

Reaction Steps

10 g. of 2-pyrrolidinone and 10 g. of p-methoxybenzoyl chloride are heated at 80°-90° C. (internal temperature) in the absence of a solvent for 1 hour. The mixture is then left to cool down and is worked-up as described in Example 3. After recrystallization from alcohol, there is obtained 1-(p-methoxybenzoyl)-2-pyrrolidinone having a melting point of 120°-121° C.

Provenance & Evidence