反应详情

A mixture of 16 parts of 1-(chloromethyl)-4-fluoro-2-methylbenzene, 7.8 parts of a solution of potassium cyanide in a small amount of water, 0.1 parts of potassium iodide and 240 parts of 2-propanone is stirred and refluxed for 22 hours. The reaction mixture is cooled and filtered. The filtrate is evaported. The residue is taken up in water and the product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 13 parts (87.2%) of 4-fluoro-2-methylbenzeneacetonitrile as a residue.

1. temperaturerefluxed for 22 hours
2. temperatureThe reaction mixture is cooled
3. filtrationfiltered
4. extractionthe product is extracted with methylbenzene
5. customThe extract is dried
6. filtrationfiltered
7. customevaporated