HRID1164383

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@@H](OCc1ccccc1)[C@H](NC(=O)OC(C)(C)C)C(=O)O

HCID1549483

N-[(1,1-Dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-threonine

C16H23NO5

结构：COC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(N)=O

HCID13190122

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CC[C@@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)OCc1ccccc1)C(N)=O

HCID70529565

未命名化合物

收率 64.7%

PROCEDURE

实验过程

Methyl t-butyloxycarbonyl-D-isoglutaminate (0.65 g, 2.5 mmol) and t-butyloxycarbonyl-O-benzyl-L-threonine (0.77 g, 2.5 mmol) were reacted by the similar procedure to that described in Example 44 (I) to obtain methyl t-butyloxycarbonyl-O-benzyl-L-threonyl-D-isoglutaminate (0.73 g). m.p. 131°-132° C. [α]D22 +7.0° (C 0.5, ethanol). Rf3 =0.39, Rf5 =0.46.