L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- → methyl t-butyloxycarbonyl-O-benzyl-L-threonyl-D-isoglutaminate

Participants

Reaction Steps

Methyl t-butyloxycarbonyl-D-isoglutaminate (0.65 g, 2.5 mmol) and t-butyloxycarbonyl-O-benzyl-L-threonine (0.77 g, 2.5 mmol) were reacted by the similar procedure to that described in Example 44 (I) to obtain methyl t-butyloxycarbonyl-O-benzyl-L-threonyl-D-isoglutaminate (0.73 g). m.p. 131°-132° C. [α]D22 +7.0° (C 0.5, ethanol). Rf3 =0.39, Rf5 =0.46.

Provenance & Evidence