反应详情

To 20 ml of chloroform was dissolved 1.0 g (3.5 m mole) of 3,4-dihydro-2-piperazinomethyl-2H-(1,3)-thiazine[3,2-a[benzimidazole, followed by the dropwise addition of 1 g of 3,4,5-trimethoxycinnamoyl chloride in 10 ml of chloroform under ice-cooled stirring conditions. After ten minutes, 0.5 ml of triethylamine was added. The mixture was stirred for 3 hours at room temperature. After the completion of the reaction, the reaction mixture was added with water and extracted with chloroform. The chloroform layer was washed with water and then dried over anhydrous magnesium sulfate. Chloroform was evaporated under reduced pressure and the residue was chromatographed on silica gel and eluted with chloroform to obtain 1.2 g (Yield: 69.4%) of the intended product, m.p. 211°-212° C.;

1. temperaturecooled
2. waitAfter ten minutes
3. stirringThe mixture was stirred for 3 hours at room temperature
4. customAfter the completion of the reaction
5. extractionextracted with chloroform
6. washThe chloroform layer was washed with water
7. dry with materialdried over anhydrous magnesium sulfate
8. customChloroform was evaporated under reduced pressure
9. customthe residue was chromatographed on silica gel
10. washeluted with chloroform