反应详情

温度

-25 °C

In methylene chloride (10 ml) are dissolved 2,2,2-trichloroethyl 7β-methoxyamino-3-methyl-3-cephem-4-carboxylate (320 mg) and pyridine (134 mg) and the mixture is cooled to -25° C. To this mixture is added phenoxyacetyl chloride (171 mg), followed by stirring for 20 minutes. The reaction mixture is poured in a mixture of ethyl acetate and water and the organic layer is taken. The organic layer is washed with 1 N-HCl, aqueous sodium hydrogen carbonate and aqeuous sodium chloride in that-order, dried over magnesium sulfate and concentrated. The above procedure gives 2,2,2-trichloroethyl 7-(N-methoxy-2-phenoxyacetamido)-3-methyl-3-cephem-4-carboxylate (510 mg).

1. washThe organic layer is washed with 1 N-HCl, aqueous sodium hydrogen carbonate and aqeuous sodium chloride in that-order,
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated