Potassium Carbonate → Piperazine, 1-(2-ethoxyphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, dihydrochloride

HRID 1164487Notes

Reaction equation

HRID 1164487 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6][Cl:7].[CH2:15]([O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)[CH3:16].C([O-])([O-])=O.[K+].[K+]>>[ClH:7].[ClH:7].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6][N:27]1[CH2:26][CH2:25][N:24]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[O:17][CH2:15][CH3:16])[CH2:29][CH2:28]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 774485-(Chloromethyl)-1,2,3-trimethoxybenzeneHCID 833571-(2-Ethoxyphenyl)piperazine

Product 1

HCID 3062137Piperazine, 1-(2-ethoxyphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, dihydrochlorideYield 81.8%

Procedure

8.3 g of 3,4,5-trimethoxybenzyl chloride and 4.1 g of N-(2-ethoxyphenyl)-piperazine and 3.5 g of K2CO3 are reacted and processed according to example 2. 7.2 g of N-(3,4,5-trimethoxy-benzyl)-N'-(2-ethoxyphenyl)-piperazine dihydrochloride is obtained. Mp.: 212° C.

Sources & evidence

ORD record
ord-5174d06c1d3049dda9b65aa8557d1cc5
Source dataset
uspto-grants-1983_01
Patent number
US04370330

Reaction notes

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