Potassium Carbonate → Piperazine, 1-(2-nitrophenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochloride

HRID 1164488Notes

Reaction equation

HRID 1164488 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6][Cl:7].[N+:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)([O-:17])=[O:16].C([O-])([O-])=O.[K+].[K+]>>[ClH:7].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6][N:27]1[CH2:28][CH2:29][N:24]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[N+:15]([O-:17])=[O:16])[CH2:25][CH2:26]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 774485-(Chloromethyl)-1,2,3-trimethoxybenzeneHCID 1009491-(2-Nitrophenyl)piperazine

Product 1

HCID 3062138Piperazine, 1-(2-nitrophenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochlorideYield 64.8%

Procedure

8.3 g of 3,4,5-trimethoxybenzyl chloride and 4.15 g of N-(2-nitrophenyl)-piperazine and 3.5 g of K2CO3 are reacted and processed according to example 2. 5.5 g of N-(3,4,5-trimethoxy-benzyl)-N'-(2-nitrophenyl)-piperazine hydrochloride is obtained. Mp.: 248° C.

Sources & evidence

ORD record
ord-62a768bfe1644fccba097cef769994a2
Source dataset
uspto-grants-1983_01
Patent number
US04370330

Reaction notes

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