Hydrochloric Acid → HCID 13469482, compound

HRID 1164587Notes

Reaction equation

HRID 1164587 reaction equation
C([O:3][CH:4](OCC)[C:5]1[NH:6][C:7]([CH:28](OCC)[O:29]CC)=[C:8]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])[C:10]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12])C.Cl>CC(C)=O>[CH:4]([C:5]1[NH:6][C:7]([CH:28]=[O:29])=[C:8]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])[C:10]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13469458HCID 13469458, compound

Product 1

HCID 13469482HCID 13469482, compoundYield 109.5%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of diethyl 2,6-bis(diethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (1.7 g) in acetone (17 ml) was added 6N-hydrochloric acid (1.5 ml) and stirred at room temperature for 3 hours. After removing the solvent, the residue was extracted with diethyl ether and the extract was washed with water and dried. The dolvent was removed from the extract to give diethyl 2,6-diformyl-4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (1.35 g). The product was recrystallized from diethyl ether to give pure yellowish granules, m.p. 85° to 86° C.

Workup

  1. customAfter removing the solvent
  2. extractionthe residue was extracted with diethyl ether
  3. washthe extract was washed with water
  4. customdried
  5. customThe dolvent was removed from the
  6. extractionextract

Sources & evidence

ORD record
ord-e2908ec09b104d4f9256202a3f5ebbde
Source dataset
uspto-grants-1983_01
Patent number
US04370334

Reaction notes

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