Sodium Hydroxide → HCID 178425375, compound

Participants

Reaction Steps

A mixture of 99.25 parts of 4-methyl-7-chloro-2-aminobenzothiazole, 20 parts of solid sodium hydroxide and the glycolic mother liquor mentioned in Example 8 is heated for 4 hours with agitation at 160°-165° C. The batch is then cooled with agitation to a temperature of 20°-30° C., and operations for cyclization of the precipitated sodium salt of 6-methyl-3-chloro-2-mercaptophenylurea are as indicated in Example 8. 85 Parts of 7-chloro-4-methyl-2-hydroxybenzothiazole having a melting point of 265.5°-266° C. are obtained, which corresponds to a yield of 85.2% of th.

Provenance & Evidence