Sodium Hydroxide → HCID 178425375, compound

HRID 1164652Notes

Reaction equation

HRID 1164652 reaction equation
CC1C2N=C(N)SC=2C(Cl)=CC=1.[OH-].[Na+].[Na].[CH3:16][C:17]1[C:22]([NH:23][C:24](N)=[O:25])=[C:21]([SH:27])[C:20]([Cl:28])=[CH:19][CH:18]=1>>[Cl:28][C:20]1[C:21]2[S:27][C:24]([OH:25])=[N:23][C:22]=2[C:17]([CH3:16])=[CH:18][CH:19]=1

Participants

5

Reactant 4

HCID 14798Sodium HydroxideHCID 20498937-chloro-4-methyl-benzothiazol-2-ylamineHCID 5360545SodiumHCID 54038952HCID 54038952, compound

Product 1

HCID 178425375HCID 178425375, compoundYield 85.2%

Procedure

A mixture of 99.25 parts of 4-methyl-7-chloro-2-aminobenzothiazole, 20 parts of solid sodium hydroxide and the glycolic mother liquor mentioned in Example 8 is heated for 4 hours with agitation at 160°-165° C. The batch is then cooled with agitation to a temperature of 20°-30° C., and operations for cyclization of the precipitated sodium salt of 6-methyl-3-chloro-2-mercaptophenylurea are as indicated in Example 8. 85 Parts of 7-chloro-4-methyl-2-hydroxybenzothiazole having a melting point of 265.5°-266° C. are obtained, which corresponds to a yield of 85.2% of th.

Workup

  1. temperatureis heated for 4 hours with agitation at 160°-165° C

Sources & evidence

ORD record
ord-6c43c8c6dfb0463d9d258b806efe3037
Source dataset
uspto-grants-1983_01
Patent number
US04370483

Reaction notes

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