反应详情

5.1 g (0.03 mole) of trimethylpyruvic acid N-acetylamide in 20 ml of ethanol were added dropwise to 3.2 g (0.03 mole) of thiocarbohydrazide in 50 ml of 1 N HCl and the reaction mixture was subsequently stirred at room temperature for 5 hours. The product which had precipitated was filtered off, washed with water and dried. 5.7 g of the above product of formula (V) of melting point 210° C. were obtained with a content, determined by gas chromatography, of >99%, which corresponded to a yield of 95% of theory.

1. customThe product which had precipitated
2. filtrationwas filtered off
3. washwashed with water
4. customdried