Potassium Carbonate → 2-Phenylpropionic acid

HRID 1164758Notes

Reaction equation

HRID 1164758 reaction equation
Cl[CH:2](C)[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[C:12](=O)([O-:14])[O-:13].[K+].[K+].[Hg:18]>CO>[C:5]1([CH:3]([CH3:2])[C:12]([OH:14])=[O:13])[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1.[Hg:18]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 23931MercuryHCID 2212812-Chloropropiophenone

Product 2

HCID 102962-Phenylpropionic acidHCID 23931Mercury

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution comprising 5 parts of α-chloropropiophenone and 3 parts of anyhydrous potassium carbonate in 300 parts of anhydrous methyl alcohol was irradiated by means of a medium pressure 200W mercury vapour lamp for 6 hours at 30° C. The solvent was removed by distillation and the resulting methyl ester of α-phenyl propionic acid was treated with 10% w/v aqueous alcoholic sodium hydroxide at 100° C. for 3 hours to effect hydrolysis and thereby to yield 3.2 parts of α-phenyl propionic acid b.p. 125° C. at 20 mm mercury.

Workup

  1. customThe solvent was removed by distillation
  2. additionthe resulting methyl ester of α-phenyl propionic acid was treated with 10% w/v aqueous alcoholic sodium hydroxide at 100° C. for 3 hours
  3. customhydrolysis

Sources & evidence

ORD record
ord-1148093dfc9f4539bce02c20aeaf5ff4
Source dataset
uspto-grants-1990_03
Patent number
US04906343

Reaction notes

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