反应详情

A solution of 20.4 g (61.7 mmol) of N-[2-[[(3,5-diamino-6-chloropyrazinyl)carbonyl]amino]ethyl]-N-methyl-beta-alanine methyl ester and 36.0 g (0.6 mol) of ethylenediamine was heated at 40° C. fdr 2 days under an inert atmosphere. The excess ethylene diamine was evaporated. The residue was triturated with 2-propanol. There was obtained 15.2 g (44.4 mmol 72%) of 3,5-diamino-N-[2-[[3-[(2-aminoethyl)amino]-3-oxopropyl]methylamino]ethyl]-6-chloropyrazinecarboxamide as a white solid; mp 140°-142° C.; Rf =0.27, Solvent System A.

1. customThe excess ethylene diamine was evaporated
2. customThe residue was triturated with 2-propanol