(R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane → HCID 18637940, compound

HRID 1164901Notes

Reaction equation

HRID 1164901 reaction equation
[N:1]1[N:2]=[N:3][N:4]2[CH:9]=[C:8]([C@@H:10]3[CH2:12][O:11]3)[CH:7]=[CH:6][C:5]=12.[NH2:13][C:14]([CH3:25])([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[OH:24])[CH3:15]>C(O)C>[CH3:25][C:14]([NH:13][CH2:12][C@@H:10]([C:8]1[CH:7]=[CH:6][C:5]2[N:4]([N:3]=[N:2][N:1]=2)[CH:9]=1)[OH:11])([CH3:15])[CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[OH:24]

Participants

4

Reactant 2

HCID 13090314(R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxiraneHCID 198636832-(3-Amino-3-methylbutyl)phenol

Product 1

HCID 18637940HCID 18637940, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 156 mg (1.46 mmol) of (R)-2-(tetrazolo[1,5-a]pyrid-6-yl)oxirane and 170 ml of 2-amino-2-methyl-4-(2-hydroxyphenyl)butane in 15 ml of absolute ethanol is heated at reflux for 6 hours. The reaction mixture is concentrated and the residue chromatographed on silica gel to give the desired product.

Workup

  1. temperatureat reflux for 6 hours
  2. concentrationThe reaction mixture is concentrated
  3. customthe residue chromatographed on silica gel

Sources & evidence

ORD record
ord-58a67f93f3ad45e68a3671795e824064
Source dataset
uspto-grants-1990_03
Patent number
US04906645

Reaction notes

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