Acetic Acid → HCID 19909838, compound

HRID 1164904Notes

Reaction equation

HRID 1164904 reaction equation
Br.[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][C:8]1[CH2:12][C:11](=[O:13])[NH:10][N:9]=1.[C:14]([OH:17])(=O)[CH3:15]>>[OH:17][C:14]1[CH:15]=[CH:12][C:8]([N:10]2[C:11](=[O:13])[CH2:12][C:8]([CH2:7][C:3]3[NH:2][CH:6]=[CH:5][N:4]=3)=[N:9]2)=[CH:7][CH:3]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 67835946HCID 67835946, compound

Product 1

HCID 19909838HCID 19909838, compound

Procedure

To a mixture of 1 ml of 47% hydrobromic acid and 1 ml of acetic acid was added 100 mg of 3-(1-imidazolylmethyl)-2-pyrazolin-5-one and stirred under reflux for 4 hours. After removing the solvent by evaporating, the residue was adjusted in pH to 4 by adding water and an aqueous NaHCO3 solution and then extracted with a mixed solvent of chloroform and ethanol (4:1).

Workup

  1. temperatureunder reflux for 4 hours
  2. customAfter removing the solvent
  3. customby evaporating
  4. additionby adding water
  5. extractionan aqueous NaHCO3 solution and then extracted with a mixed solvent of chloroform and ethanol (4:1)

Sources & evidence

ORD record
ord-c86be503df834de1a5726323f448e9dd
Source dataset
uspto-grants-1990_03
Patent number
US04906644

Reaction notes

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