Cyclopropylamine → HCID 86743792, compound

HRID 1164910Notes

Reaction equation

HRID 1164910 reaction equation
[Cl:1][C:2]1([S:8](Cl)(=[O:10])=[O:9])[NH:6][C:5]([Cl:7])=[CH:4][S:3]1.[CH:12]1([NH2:15])[CH2:14][CH2:13]1>>[CH:12]1([NH:15][S:8]([C:2]2([Cl:1])[NH:6][C:5]([Cl:7])=[CH:4][S:3]2)(=[O:10])=[O:9])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 22164315HCID 22164315, compound

Product 1

HCID 86743792HCID 86743792, compound

Procedure

In analogy to Example 2, the N-cyclopropyl-2,4-dichlorothiazolesulphonamide was prepared by reacting 2,4-dichlorothiazole-sulphonyl chloride from Example 1 with anhydrous cyclopropylamine. Following recrystallization from toluene, 24.4 g of product were obtained (89.2% of the theoretical yield), m.p.: 90°-91° C.

Workup

  1. customrecrystallization from toluene

Sources & evidence

ORD record
ord-1466d134cfd6486d9b9ba11c863c0d66
Source dataset
uspto-grants-1990_03
Patent number
US04906650

Reaction notes

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