反应详情

2,6-Dimethoxy-benzoic acid is converted to 2,6-dimethoxybenzoyl chloride III by treatment with thionyl chloride at 70° C. for 2 hours and after removal of excess thionyl chloride the residual III is dissolved in toluene and treated at -78° C. with a solution of triethylaluminum in toluene. This procedure provides 1-(2,6-dimethoxyphenyl)propan-1-one IV in two steps from the readily available precursor II.

1. customafter removal of excess thionyl chloride the residual III
2. dissolutionis dissolved in toluene
3. additiontreated at -78° C. with a solution of triethylaluminum in toluene