2,6-Dimethoxybenzoic Acid → 1-(2,6-Dimethoxyphenyl)propan-1-one

HRID 1164924ノート

反応式

HRID 1164924 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[C:4]=1[C:5]([OH:7])=O.CO[C:16]1C=CC=C(OC)[C:17]=1C(Cl)=O.S(Cl)(Cl)=O>>[CH3:13][O:12][C:8]1[CH:9]=[CH:10][CH:11]=[C:3]([O:2][CH3:1])[C:4]=1[C:5](=[O:7])[CH2:16][CH3:17]

参加物

4

反応物 3

HCID 151092,6-Dimethoxybenzoic AcidHCID 24386Thionyl ChlorideHCID 748102,6-Dimethoxybenzoyl chloride

生成物 1

HCID 148501551-(2,6-Dimethoxyphenyl)propan-1-one

実験手順

2,6-Dimethoxy-benzoic acid is converted to 2,6-dimethoxybenzoyl chloride III by treatment with thionyl chloride at 70° C. for 2 hours and after removal of excess thionyl chloride the residual III is dissolved in toluene and treated at -78° C. with a solution of triethylaluminum in toluene. This procedure provides 1-(2,6-dimethoxyphenyl)propan-1-one IV in two steps from the readily available precursor II.

後処理

  1. customafter removal of excess thionyl chloride the residual III
  2. dissolutionis dissolved in toluene
  3. additiontreated at -78° C. with a solution of triethylaluminum in toluene

出典と根拠

ORDレコード
ord-1c4f17288b9d4f818ff21f5af7e61c18
出典データセット
uspto-grants-1990_03
特許番号
US04906658

反応ノート

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