HCID 54387892, compound → HCID 19863457, compound

HRID 1164972Notes

Reaction equation

HRID 1164972 reaction equation
[CH2:1]([N:3]([CH2:26][CH3:27])[CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][C:8]=1[C:16](=[O:25])[CH:17]=[CH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:2]>C(O)C.[Pd]>[NH2:13][C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][CH2:4][N:3]([CH2:26][CH3:27])[CH2:1][CH3:2])=[C:8]([C:16](=[O:25])[CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:9]=1

Participants

4

Reactant 1

HCID 54387892HCID 54387892, compound

Product 1

HCID 19863457HCID 19863457, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To 5.0 g (13.6 mmol) of 1-[2-[2-(diethylamino)ethoxy]-5-nitrophenyl]-3-phenyl-2-propen-1-one in 250 mL of ethanol add 0.5 g of palladium on carbon (10%). Hydrogenate the mixture at 22 psi until the theoretical amount of hydrogen has been absorbed. Filter the reaction and remove the solvent in vacuo to provide the title compound.

Workup

  1. customHydrogenate the mixture at 22 psi until the theoretical amount of hydrogen has been absorbed
  2. filtrationFilter
  3. customthe reaction
  4. customremove the solvent in vacuo

Sources & evidence

ORD record
ord-855f11f993ef4e9fac3435435e3368e6
Source dataset
uspto-grants-1990_03
Patent number
US04906634

Reaction notes

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