Methanesulfonic anhydride → HCID 86743799, compound

HRID 1164981Notes

Reaction equation

HRID 1164981 reaction equation
[NH2:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C@@H:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C@H:8]2[N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])=[CH:4][CH:3]=1.[CH3:20][S:21]([O:24]S(C)(=O)=O)(=[O:23])=[O:22]>C(#N)C>[CH3:20][S:21]([OH:24])(=[O:23])=[O:22].[CH2:16]([N:13]([CH2:14][CH3:15])[C@@H:8]1[CH2:9][CH2:10][CH2:11][CH2:12][C@H:7]1[O:6][C:5]1[CH:18]=[CH:19][C:2]([NH:1][S:21]([CH3:20])(=[O:23])=[O:22])=[CH:3][CH:4]=1)[CH3:17]

Participants

4

Reactant 2

HCID 81560Methanesulfonic anhydrideHCID 18637925HCID 18637925, compound

Product 1

HCID 86743799HCID 86743799, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To 3.16 g (12 mmol) of trans-2-(4-aminophenoxy)-N,N-diethylcyclohexanamine in 20 mL of acetonitrile under an N2 atmosphere add 2.10 g (10 mmol) of methanesulfonic acid anhydride. Stir the reaction for 3 h at 50° C. Cool the reaction mixture and remove the solvent in vacuo. Recrystallize the resulting product from acetone/ether to afford the title compound.

Workup

  1. customthe reaction for 3 h at 50° C
  2. temperatureCool the reaction mixture
  3. customremove the solvent in vacuo
  4. customRecrystallize the resulting product from acetone/ether

Sources & evidence

ORD record
ord-b5bdb4987b0b46a2a39514b69d55b515
Source dataset
uspto-grants-1990_03
Patent number
US04906634

Reaction notes

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