Methanesulfonic anhydride → HCID 86743800, compound

HRID 1164984Notes

Reaction equation

HRID 1164984 reaction equation
[NH2:1][C:2]1[CH:15]=[C:14]([CH3:16])[C:5]([O:6][CH2:7][CH2:8][N:9]([CH2:12][CH3:13])[CH2:10][CH3:11])=[C:4]([CH3:17])[CH:3]=1.[CH3:18][S:19]([O:22]S(C)(=O)=O)(=[O:21])=[O:20]>C(#N)C>[CH3:18][S:19]([OH:22])(=[O:21])=[O:20].[CH2:10]([N:9]([CH2:12][CH3:13])[CH2:8][CH2:7][O:6][C:5]1[C:14]([CH3:16])=[CH:15][C:2]([NH:1][S:19]([CH3:18])(=[O:21])=[O:20])=[CH:3][C:4]=1[CH3:17])[CH3:11]

Participants

4

Reactant 2

HCID 81560Methanesulfonic anhydrideHCID 19863418HCID 19863418, compound

Product 1

HCID 86743800HCID 86743800, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To 4.55 g (19.3 mmol) of 2-(4-amino-2,6-dimethylphenoxy)-N,N-diethylethanamine in 40 mL of acetonitrile add 3.40 g (19.5 mmol) of methanesulfonic anhydride. After the addition is complete, stir the reaction for 2 hours at 50° C. Remove the solvent in vacuo. Recrystallize the residue from acetone/ether to obtain the title compound.

Workup

  1. additionAfter the addition
  2. customthe reaction for 2 hours at 50° C
  3. customRemove the solvent in vacuo
  4. customRecrystallize the residue from acetone/ether

Sources & evidence

ORD record
ord-6785026561d345e7864ca04807f19f11
Source dataset
uspto-grants-1990_03
Patent number
US04906634

Reaction notes

Loading…