Ethyl Acetate → Acetamide, N-(2-amino-2-methylpropyl)-

HRID 1164987Notes

Reaction equation

C([O:4][CH2:5][CH3:6])(=O)C.[NH2:7][CH2:8][C:9]([NH2:12])([CH3:11])[CH3:10]>>[CH3:10][C:9]([NH2:12])([CH3:11])[CH2:8][NH:7][C:5](=[O:4])[CH3:6]

Participants

Reactant 2

HCID 8857Ethyl Acetate

HCID 131282-Methylpropylenediamine

Product 1

HCID 9793774Acetamide, N-(2-amino-2-methylpropyl)-Yield 57.4%

Conditions

Temperature: 100 °C

Procedure

A mixture of 26.4 g (0.3 mol) of ethyl acetate and 79.2 g (0.9 mole) of 1,2-diamino-2-methylpropane was heated at 100° C. in a pressured bomb for 36 hours. The reaction mixture was evaporated in vacuo and distilled to give 22.4 g (57.4%) of product which had a boiling point of 100° C. at 0.1 mmHg. This product was identified by NMR and IR spectroscopy.

Workup

customThe reaction mixture was evaporated in vacuo
distillationdistilled

Sources & evidence

ORD record: ord-ca5f99ed2037435b8df20c81c1163053
Source dataset: uspto-grants-1990_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04906661

Reaction notes

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