Hydrochloric Acid → HCID 15617827, compound

HRID 1165009Notes

Reaction equation

HRID 1165009 reaction equation
Cl.[CH3:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].C([O:11][CH2:12][CH3:13])(=O)C.[CH2:14](O)[CH3:15]>>[C:4]1([C:15]2[CH:14]=[CH:7][C:6]3[C:13](=[CH:2][CH:3]=[CH:4][CH:5]=3)[C:12]=2[OH:11])[CH2:3][CH2:2][CH2:7][CH2:6][CH:5]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 21226206Ethyl acetate hexane

Product 1

HCID 15617827HCID 15617827, compoundYield 62%

Procedure

A solution of the product of Part A (3.30 g, 0.012 mole) in ethanol (100 mL) and 1.0N hydrochloric acid (100 mL) was stirred at room temperature for 5 hours. The ethanol was removed under reduced pressure, and the crude product was isolated by extraction with ethyl acetate. Chromatography with 95:5 hexane/ethyl acetate provided a white solid which was recrystallized (hexane) to give the title compound (1.59 g, 62%) as white crystals, mp 82°-83°.

Workup

  1. customThe ethanol was removed under reduced pressure
  2. customthe crude product was isolated by extraction with ethyl acetate
  3. customwas recrystallized (hexane)

Sources & evidence

ORD record
ord-023bf5259b7849adadfcac9f34ceda75
Source dataset
uspto-grants-1990_03
Patent number
US04906636

Reaction notes

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