Water → HCID 15617921, compound

HRID 1165022Notes

Reaction equation

HRID 1165022 reaction equation
O[C:2]([CH3:19])([CH3:18])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]=1[OH:17].C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1(C)C=CC=CC=1>[CH3:18][C:2]([CH3:19])=[CH:3][CH2:4][CH2:5][CH2:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]=1[OH:17]

Participants

5

Reactant 3

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 15617920HCID 15617920, compound

Product 1

HCID 15617921HCID 15617921, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of the compound of Example 119 (0.45 g, 0.002 mole) and p-toluenesulfonic acid (4-5 crystals) in toluene (20 mL) was heated at reflux with azeotropic removal of water. After 18 hours, the cooled solution was washed with saturated aqueous sodium bicarbonate and evaporated to provide the title compound (0.45 g, 100%) as an oil; mass spectrum: m/z 240.

Workup

  1. washthe cooled solution was washed with saturated aqueous sodium bicarbonate
  2. customevaporated

Sources & evidence

ORD record
ord-e1f0abf063654898bef433c361a0994c
Source dataset
uspto-grants-1990_03
Patent number
US04906636

Reaction notes

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