HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 3-Bromo-6,8-dimethylimidazo[1,2-b]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 6,8-Dimethylimidazo[1,2-b]pyridazine | HCID 14750357 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-Bromo-6,8-dimethylimidazo[1,2-b]pyridazine | HCID 14750356 | 83.5% |
Reaction Steps
To a solution of 3.63 g (24.7 mmol) of 6,8-dimethylimidazo[1,2-b]pyridazine in 25 mL of chloroform was added 4.84 g (27.2 mmol) of N-bromosuccinimide. After 2 h. 1 mL of a saturated aqueous solution of sodium bicarbonate was added. The layers were separated. The organic layer was dried (Na2SO4) and the solvent was removed with a rotary evaporator. The residue was purified by flash chromatography to give 4.66 g of the title compound as a while solid, m.p. 137°-139° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04908056 |
| Source dataset | uspto-grants-1990_03 |
| ORD ID | ord-a4a46ebb4e52495c907b3c9eecae474a |
| Source note | uspto-grants-1990_03 |