Lawesson's reagent → HCID 70373898, compound

HRID 1165128Notes

Reaction equation

HRID 1165128 reaction equation
[S:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]1[C:11](=O)[CH2:12][NH:13][C:14](=O)[C:15]1[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:37])=CC=1>C1(C)C=CC=CC=1>[F:23][C:22]([F:25])([F:24])[O:21][C:18]1[CH:19]=[CH:20][C:15]([C:14]2[S:37][C:11]([CH:2]3[CH:3]=[CH:4][C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[S:1]3)=[CH:12][N:13]=2)=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 70373866HCID 70373866, compound

Product 1

HCID 70373898HCID 70373898, compoundYield 88.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In a manner similar to Step E of Example 1, the reaction of 1.0 g (0.0026 mole) of N-[2-(thianaphthalene-2-yl)-2oxoethyl]-4-trifluoromethoxybenzamide with 0.53 g (0.0013 mole) of Lawesson's reagent in 25 ml of toluene yielded 0.45 g of 2-(4-trifluoromethoxyphenyl)-5-(thianaphthalene-2-yl)thiazole as a solid, mp 65-69, compound 40 of Table 1.

Sources & evidence

ORD record
ord-aead140f719549fd8598911580f1c399
Source dataset
uspto-grants-1990_03
Patent number
US04908357

Reaction notes

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