HCID 56613324, compound → HCID 19862543, compound

HRID 1165148Notes

Reaction equation

HRID 1165148 reaction equation
[OH:1][C:2]1[C:16]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:15][C:5]([CH2:6][NH:7][N:8]2[CH:12]=[CH:11][N:10]=[C:9]2SC)=[CH:4][C:3]=1[C:21]([CH3:24])([CH3:23])[CH3:22]>C(O)C>[OH:1][C:2]1[C:16]([C:17]([CH3:19])([CH3:18])[CH3:20])=[CH:15][C:5]([CH2:6][NH:7][N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)=[CH:4][C:3]=1[C:21]([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 1

HCID 56613324HCID 56613324, compound

Product 1

HCID 19862543HCID 19862543, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Variant (b): 600 mg of 1-(4-hydroxy-3,5-di-tert.-butylbenzylamino)-2-methylmercaptoimidazole dissolved in 20 ml of ethanol are heated to 60°-70° for 2 hours while stirring with a 5-fold amount by weight of ethanol-moist Raney-nickel W2. The nickel is then removed by filtration and boiled up twice with 10 ml of ethanol each time. The combined alcoholic filtrates are evaporated, and 1-(4-hydroxy-3,5-di-tert.-butylbenzylamino)imidazole is obtained as the residue in the form of colorless crystals of m.p. 171°-174°.

Workup

  1. temperatureare heated to 60°-70° for 2 hours
  2. customThe nickel is then removed by filtration
  3. customThe combined alcoholic filtrates are evaporated

Sources & evidence

ORD record
ord-7b8c84d8210f4388a72ced3388660d5c
Source dataset
uspto-grants-1990_03
Patent number
US04908363

Reaction notes

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