反应详情

A mixture of potassium 2-cyanonicotinate (4.1 g; 0.022 mole), 4-chloromethyl-2-methylthiazole (2.95 g; 0.02 mole) and 18-crown-6-ether (0.13 g; 0.0005 mole) in acetonitrile (50 cc) is brought to reflux for 8 hours. The solvent is then evaporated off and the residue taken up in water and extracted with dichloromethane. After drying, evaporation of the dichloromethane and purification by chromatography on a silica column, Compound 1(2.12 g; 41%; m.p. 93° C.) is obtained.

1. temperatureto reflux for 8 hours
2. customThe solvent is then evaporated off
3. extractionextracted with dichloromethane
4. customAfter drying
5. customevaporation of the dichloromethane and purification by chromatography on a silica column