反应详情

With stirring, 0.56 ml of triethylamine is added at room temperature to a suspension of 0.556 g of 3-hydroxy-1,2-dimethyl-4(1H)-pyridinone in 40 ml of acetonitrile and 40 ml of methylene chloride, followed by the addition of 1.02 ml of caprylyl chloride. A solution forms within 3 minutes and after 30 minutes the reaction is complete, and the volatile constituents are removed by evaporation under reduced pressure. The residue is dried under a high vacuum and crystallised from a mixture of methylene chloride and ethyl acetate. The 3-(n-octanoyloxy)-1,2-dimethyl-4-(1H)-pyridinone so obtained begins to sinter at 140° C. and decomposes at 180° C.

1. waitafter 30 minutes the reaction is complete
2. customthe volatile constituents are removed by evaporation under reduced pressure
3. customThe residue is dried under a high vacuum
4. customcrystallised from a mixture of methylene chloride and ethyl acetate