Hydrochloric Acid → HCID 19862592, compound

Participants

Reaction Steps

A mixture of 18.0 g of the 3-benzyloxy-1-(2-methoxyethyl)-2-methyl-4(1H)-pyridinone so obtained and 100 ml of fuming aqueous hydrochloric acid is refluxed for 2 minutes, cooled, diluted with isopropanol, and concentrated by evaporation under reduced pressure. The 3-hydroxy-1-(2-methoxyethyl)-2-methyl-4(1H)-pyridinone hydrochloride obtained as crystalline residue is further purified by recrystallisation from ethyl acetate and isopropanol.

Provenance & Evidence