Hydrochloric Acid → HCID 19862592, compound

HRID 1165173Notes

Reaction equation

HRID 1165173 reaction equation
C([O:8][C:9]1[C:14](=[O:15])[CH:13]=[CH:12][N:11]([CH2:16][CH2:17][O:18][CH3:19])[C:10]=1[CH3:20])C1C=CC=CC=1.[ClH:21]>C(O)(C)C>[ClH:21].[OH:8][C:9]1[C:14](=[O:15])[CH:13]=[CH:12][N:11]([CH2:16][CH2:17][O:18][CH3:19])[C:10]=1[CH3:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14956283HCID 14956283, compound

Product 1

HCID 19862592HCID 19862592, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 18.0 g of the 3-benzyloxy-1-(2-methoxyethyl)-2-methyl-4(1H)-pyridinone so obtained and 100 ml of fuming aqueous hydrochloric acid is refluxed for 2 minutes, cooled, diluted with isopropanol, and concentrated by evaporation under reduced pressure. The 3-hydroxy-1-(2-methoxyethyl)-2-methyl-4(1H)-pyridinone hydrochloride obtained as crystalline residue is further purified by recrystallisation from ethyl acetate and isopropanol.

Workup

  1. customso obtained
  2. temperaturecooled
  3. concentrationconcentrated by evaporation under reduced pressure

Sources & evidence

ORD record
ord-b70778f0c489474bb968c44028334f7f
Source dataset
uspto-grants-1990_03
Patent number
US04908371

Reaction notes

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