Epichlorohydrin → HCID 20098382, compound

HRID 1165241Notes

Reaction equation

HRID 1165241 reaction equation
[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([C:7]([NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[C:15]3[C:11]=2[CH:12]=[CH:13][NH:14]3)=[O:8])=[C:5]([OH:21])[CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:28]([CH:30]1[O:32][CH2:31]1)Cl>CC(C)=O>[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([C:7]([NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[C:15]3[C:11]=2[CH:12]=[CH:13][NH:14]3)=[O:8])=[C:5]([O:21][CH2:28][CH:30]2[CH2:31][O:32]2)[CH:4]=1

Participants

5

Reactant 3

HCID 7835EpichlorohydrinHCID 11430Potassium CarbonateHCID 20098401HCID 20098401, compound

Product 1

HCID 20098382HCID 20098382, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Using the procedure of Step D of Example 52, 5 g of the product of Step A, 150 ml of acetone, 2.45 g of potassium carbonate and 14 ml of epichlorohydrin were reacted to obtain 7.3 g of 4-methoxy-2-[(2-oxiranyl)-methoxy]-N-(1H-indol-4-yl)-benzamide melting at 157° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-5e365c784edc4a608089e400062a3dc2
Source dataset
uspto-grants-1990_03
Patent number
US04908367

Reaction notes

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