Epichlorohydrin → HCID 20098398, compound

HRID 1165244Notes

Reaction equation

HRID 1165244 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](O)[CH:5]=[C:6]([CH:19]=1)[C:7]([NH:9][C:10]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:11]=1[CH:12]=[CH:13][NH:14]2)=[O:8].[C:21](=[O:24])([O-])[O-].[K+].[K+].C([CH:29]1[O:31][CH2:30]1)Cl>CC(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][CH2:5][C:6]([O:31][CH2:30][CH:29]2[CH2:21][O:24]2)([CH:19]=1)[C:7]([NH:9][C:10]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:11]=1[CH:12]=[CH:13][NH:14]2)=[O:8]

Participants

5

Reactant 3

HCID 7835EpichlorohydrinHCID 11430Potassium CarbonateHCID 20098356HCID 20098356, compound

Product 1

HCID 20098398HCID 20098398, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Using the procedure of Step D of Example 52, 3 g of the product of Step A, 100 ml of acetone, 1.47 g of potassium carbonate and 8.3 ml of epichlorohydrin were reacted to obtain 3.35 g of 5-chloro-1-[(2-oxiranyl)-methoxy]-N-(1H-indol-4-yl)-benzamide melting at 175° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-0571072d8da541b586f644d834a76f8f
Source dataset
uspto-grants-1990_03
Patent number
US04908367

Reaction notes

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