反应详情

A solution of 4.22 g of 8-hydroxy-5-eicosynoic acid, the product of Example 1d, in 200 ml of acetone with vigorous stirring at 5° was added 5.5 ml of Jone's reagent (2.67M). The reaction mixture was stirred for 30 min and then 700 ml of Et2O and 2 ml of MeOH was added and stirred for additional 3 min. The resulting reaction mixture was washed with H2O, saturated NaCl solution and dried over MgSO4. The crude product after removal of solvent was recrystallized in cyclohexane to yield the title compound, mp 79°-80.5°.

1. stirringstirred for additional 3 min
2. customThe resulting reaction mixture
3. washwas washed with H2O, saturated NaCl solution
4. dry with materialdried over MgSO4
5. customThe crude product after removal of solvent
6. customwas recrystallized in cyclohexane