Potassium Hydroxide → HCID 14072318, compound

HRID 1165432Notes

Reaction equation

HRID 1165432 reaction equation
[Br:1][C:2]1[C:3](=[O:17])[N:4]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[N:5]=[CH:6][C:7]=1Br.[Cl:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23][OH:24])=[C:21]([F:27])[CH:20]=1.[OH-].[K+]>CN(C)C=O>[Br:1][C:2]1[C:3](=[O:17])[N:4]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[N:5]=[CH:6][C:7]=1[O:24][CH2:23][C:22]1[CH:25]=[CH:26][C:19]([Cl:18])=[CH:20][C:21]=1[F:27]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 2773609(4-Chloro-2-fluorophenyl)methanolHCID 13881625HCID 13881625, compound

Product 1

HCID 14072318HCID 14072318, compoundYield 54.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a mixture of 2.0 g (5.0 m mol) of 4,5-dibromo-2-(3,4-dichlorophenyl)-3(2H)-pyridazinone and 0.84 g (5.2 m mol) of 4-chloro-2-fluorobenzyl alcohol was added 80 ml of N,N-dimethylformamide. The resulting mixture was cooled with ice, incorporated with 0.4 g of potassium hydroxide and then stirred for one day. Then, the procedures in Synthesis Example 2 were repeated to give a crude product. The crude product was recrystallized from benzene to give 1.3 g of the intended compound.

Workup

  1. customThen, the procedures in Synthesis Example 2
  2. customto give a crude product
  3. customThe crude product was recrystallized from benzene

Sources & evidence

ORD record
ord-38a1524017a943dd937f8743c9068715
Source dataset
uspto-grants-1990_03
Patent number
US04910201

Reaction notes

Loading…