Benzaldehyde → 5-tert-Butyl-2-hydroxy-3-(methanesulfonyl)benzaldehyde

HRID 1165442Notes

Reaction equation

HRID 1165442 reaction equation
[CH:1](=[O:8])C1C=CC=CC=1.[CH3:9][S:10]([C:13]1[CH:18]=[C:17]([C:19]([CH3:22])([CH3:21])[CH3:20])[CH:16]=[CH:15][C:14]=1[OH:23])(=[O:12])=[O:11]>>[OH:23][C:14]1[C:13]([S:10]([CH3:9])(=[O:11])=[O:12])=[CH:18][C:17]([C:19]([CH3:20])([CH3:22])[CH3:21])=[CH:16][C:15]=1[CH:1]=[O:8]

Participants

3

Reactant 2

HCID 240BenzaldehydeHCID 127215634-tert-Butyl-2-(methanesulfonyl)phenol

Product 1

HCID 134237195-tert-Butyl-2-hydroxy-3-(methanesulfonyl)benzaldehydeYield 53%

Procedure

The benzaldehyde used in Example 4 was prepared in a similar manner to that described for Example 3. From 7.40 g (32.4 mmol) of 2-methylsulfonyl-4-(1,1-dimethylethyl)phenol (see German Offenlegungsschrift DE 32 08 190 Al to Englert et al, assigned to Hoechst AG as an example of how to obtain this material) there was obtained 4.41 g (17.2 mmol, 53%) of 2-hydroxy-3-methylsulfonyl-5-(1,1-dimethylethyl)benzaldehyde; mp 133°-135° C.

Workup

  1. customwas prepared in a similar manner to that
  2. customto obtain this material) there

Sources & evidence

ORD record
ord-d862186e1f744c36a49da482cccf5f4d
Source dataset
uspto-grants-1990_03
Patent number
US04910202

Reaction notes

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