Testosterone → HCID 86740365, compound

Participants

Reaction Steps

To obtain the compounds of the present invention in which R4 is =CH2, 17β-hydroxy-10-(2-propynyl)estr-4-en-3-one is used as the starting material. This testosterone derivative is subjected to a Wittig reaction to give 3-methylene-10-(2-propynyl)estr-4-en-17β-ol. The 17-hydroxy group is then oxidized to the corresponding ketone and a hydroxyacetyl side chain is introduced at the 17-position using methyl methoxyacetate and the general procedure described earlier.

Provenance & Evidence