Pyridine → 1H-Indole-2-carboxamide

HRID 1165456Notes

Reaction equation

HRID 1165456 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10](Cl)=[O:11].[N:13]1C=CC=CC=1>C(Cl)Cl>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([NH2:13])=[O:11]

Participants

4

Reactant 2

HCID 1049PyridineHCID 118162081H-indole-2-carbonyl Chloride

Product 1

HCID 5948321H-Indole-2-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Indolyl carboxylic acid amides as starting materials may be produced by reacting an indolyl carboxylic acid chloride in absolute methylene chloride with an amine in the presence of pyridine at -10° to 0°.

Workup

  1. custommay be produced
  2. customat -10° to 0°

Sources & evidence

ORD record
ord-5e960840b0ed410082e2453f62e812e4
Source dataset
uspto-grants-1990_03
Patent number
US04910207

Reaction notes

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