反应详情

A solution of 150 g of 4-chlorophenyl 1-bromo-3-chloropropyl ketone in 200 ml of acetone is added dropwise to a boiling solution of 100 g of potassium carbonate and 110 g of 1,2,4-triazole in 400 ml of acetone, and the mixture is then stirred under reflux for 8 hours. It is then evaporated in vacuo, and the residue is stirred in 500 ml of water. The precipitate which separates out is filtered off with suction, washed several times with water and dried. 104 g (82% of theory) of 1-(4-chlorobenzoyl)-1-(1,2,4-triazol-1-yl)cyclopropane, of melting point 78° C., are obtained.

1. temperatureunder reflux for 8 hours
2. customIt is then evaporated in vacuo
3. stirringthe residue is stirred in 500 ml of water
4. filtrationThe precipitate which separates out is filtered off with suction
5. washwashed several times with water
6. customdried