反应详情

A mixture of 44.3 g of 4-chlorophenyl 1,2,4-triazol-1-ylmethyl ketone, 19.6 g of 1-hydroxymethyl-1,2,4-triazole, 300 ml of toluene, 6 g of acetic acid and 2 ml of piperidine is heated under a water separator until separation of water is complete. The mixture is allowed to cool, and the resulting crystalline precipitate is filtered off with suction and washed with diisopropyl ether. 47 g (76% of theory) of 1-(4-chlorophenyl)-2,3-di(1,2,4-triazol-1-yl)-1-propanone of melting point 204° C., are obtained.

1. temperatureto cool
2. filtrationthe resulting crystalline precipitate is filtered off with suction
3. washwashed with diisopropyl ether