Methylamine → HCID 19862186, compound

HRID 1165565Notes

Reaction equation

[C:1]1([N:7]2[C:11](=[O:12])[CH:10]=[CH:9][C:8]2=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:14][NH2:15]>>[CH3:14][NH:15][CH:9]1[CH2:10][C:11](=[O:12])[N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]1=[O:13]

Participants

Reactant 2

HCID 6329Methylamine

HCID 13662N-Phenylmaleimide

Product 1

HCID 19862186HCID 19862186, compound

Procedure

Furthermore, it is known that N-phenylmaleimide can be reacted with methylamine to give 3-methylamino-1-phenylpyrrolidine-2,5-dione which can be reduced with lithium aluminum hydride to give 3-methylamino-1-phenylpyrrolidine (J. Med. Chem. 10, 1015 (1967)).

Sources & evidence

ORD record: ord-fe09568dce92416994f0c2d17e7b9e3d
Source dataset: uspto-grants-1990_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04910319

Reaction notes

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