1,2-Dimethoxyethane → HCID 19862184, compound

HRID 1165570Notes

Reaction equation

HRID 1165570 reaction equation
[CH2:1]([N:8]1[C:12](=O)[CH2:11][C:10]([NH:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([CH3:14])[C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(COC)OC.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH2:1]([N:8]1[CH2:12][CH2:11][C:10]([NH:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([CH3:14])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 80711,2-DimethoxyethaneHCID 19862185HCID 19862185, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19862184HCID 19862184, compound

Procedure

51 g of 93% pure 1-benzyl-3-benzylamino-3-methylpyrrolidine-2,5-dione (0.154 mol) are reduced in 330 ml of dimethoxyethane using 12.4 g (0.33 mol) of lithium aluminum hydride. The work up is carried out as in A of Example 5.

Sources & evidence

ORD record
ord-17d9711e84b54987b615a614d05fa28e
Source dataset
uspto-grants-1990_03
Patent number
US04910319

Reaction notes

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