Methanol → HCID 14676894, compound

HRID 1165584Notes

Reaction equation

HRID 1165584 reaction equation
[CH3:1][NH:2][CH2:3][CH:4]1[C:9]2[N:10]([CH2:17][CH3:18])[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:8]=2[S:7][CH2:6][CH2:5]1.C[OH:20]>C(Cl)Cl>[CH3:1][NH:2][CH2:3][CH:4]1[C:9]2[N:10]([CH2:17][CH3:18])[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:8]=2[S:7](=[O:20])[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 887MethanolHCID 12803584HCID 12803584, compound

Product 1

HCID 14676894HCID 14676894, compoundYield 92.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 4-methylaminomethyl-5-ethyl-2,3,4,5-tetrahydrothiopyrano[3,2-b]indole (1.3 g) in methanol (30 ml) is mixed with an aqueous solution (10 ml) of sodium periodide (1.12 g) and kept at room temperature for 5 hours. The precipitate is filtered off and the filtrate is condensed. The residue is dissolved in methylene chloride, washed with water, dried and evaporated to give the title compound (1.28 g) as an oil: Yield 92.8%.

Workup

  1. filtrationThe precipitate is filtered off
  2. customcondensed
  3. washwashed with water
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-624ba79581b34b64932199204b6f772f
Source dataset
uspto-grants-1990_03
Patent number
US04910318

Reaction notes

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