反应详情

The 5-(2-fluorobenzylidene)-3-(2,5-difluorophenyl)imidazolidine-2,4-dione (1.25 g, 3.9 mmol), cesium carbonate (0.67 g, 2.06 mmol) and methyl iodide (0.84 g, 5.9 mmol) were allowed to stir overnight in DMF (15 mL), under a N2 atmosphere. The resulting solution was diluted with water and extracted with ethyl acetate (3×). The combined extracts were washed with brine (saturated), dried (over MgSO4), filtered and concentrated to give 1.3 grams of 5-(2-fluorobenzylidene)-3-(2,5-difluorophenyl)-1-methylimidazolidine-2,4-dione m.p. 94°-97° C. (compound 106 under Table B).

1. extractionextracted with ethyl acetate (3×)
2. washThe combined extracts were washed with brine (saturated)
3. dry with materialdried (over MgSO4)
4. filtrationfiltered
5. concentrationconcentrated